Researcher 2

University of Minnesota
Published
April 15, 2021
Location
Twin Cities, MN
Job Type
 

Description

The UMN has suspended hiring for most positions. However, we will continue hiring for positions critical to the University's mission and operations at this time. Applications are being accepted for this position and you are encouraged to apply. In-person interviews are suspended indefinitely and will be replaced by interviews in a virtual format. Thank you for your continued interest in working at the University of Minnesota.

Qualifications

All required qualifications must be documented on application materials

Required Qualifications:
-BS/BA and 1 year of related work experience in a research laboratory or equivalent combination of education and related work experience to total 5 years.
-Ability to communicate, both verbally and written, to a diverse community.
-Ability to work independently; reliable, and self-motivated.
-Ability to meet deadlines, work in a high-paced environment, as well as strong computer literacy.
-Detail orientated, highly organized and initiative driven.

Preferred Qualifications:
-Experience performing ADP-Glo kinase activity assays (96- and/or 384-well format)
-Preparation of x-ray crystallography crystals with or without small molecules
-Experience developing and validating SPR assays for protein-small molecule interactions
-Experience with small molecule purity analysis through LC-MS and 1H/13C NMR
-General knowledge of specialized data analysis software, such as GraphPad Prism
-Previous experience with preparing and maintaining IBC protocols desirable

About the Job

This position is 80% time, with full elgibility for full benefits.

Salary range- $19.00- $21.00

Summary of Position: This position is in a laboratory involved in identifying, validating, and developing new drugs against new targets for neurodegenerative diseases using medicinal chemistry, chemical biology, and digital ELISA. The candidate will assist Dr. Kathryn Nelson by managing data, performing procedures such as high-throughput screening, protein expression and purification, and assay development and similar techniques, analyzing recorded data, ensuring laboratory safety compliance, assisting in the preparation of technical reports, and maintaining laboratory supplies.

Principal Duties and Responsibilities:
40% Kinase screening bioassays
Lead the design and execution of a new high-throughput screening campaign against human kinases. Tasks include: validate, troubleshoot, and execute assays including luminescent bioassays in 96- or 384-well formats, SPR bioassays to evaluate small molecule to protein binding, and evaluation of small molecule purity through LC-MS and 1H/13C NMR.

20% Protein crystallography sample prep
Assist in the development of conditions for the growth of x-ray diffraction quality crystals of human kinases. Prepare samples for shipping to x-ray source for data collection and analysis.

10% Data analysis
Analyze, interpret, and prepare experimental data from all assays for discussion in small group meetings.

5% Writing of technical reports and articles for publications
Assist in the writing of technical reports, preparation of poster presentations, and articles for publication. Maintain current standard operating procedures (SOPs) for new experimental protocols as they are developed and validated. Review literature relating to the research. Maintain and submit IBC protocols, keep appropriate and detailed laboratory records with weekly updates, prepare reports, and present results.

5% General laboratory operations
Perform everyday tasks such as laboratory cleanup (using appropriate chemical and biosafety techniques). Maintain laboratory operations by purchasing appropriate supplies in a timely manner, preparing general laboratory buffers, autoclaving general materials as needed, and removing hazardous and chemical waste as appropriate. Additional responsibilities include keeping appropriate laboratory records, preparation of reports, and working with technicians, graduate students, and postdoctoral fellows. Expected to attend meetings where data will be presented and participate in the presentation and discussion.

About the Department

As part of the College of Pharmacy, the mission of the Institute for Therapeutics Discovery & Development (ITDD) is to carry out interdisciplinary research, help educate the next generation of scientists, and to enhance the biomedical research infrastructure at the University of Minnesota by creating opportunities for drug discovery and early pre-clinical drug development through collaborations between various schools, colleges and research centers, as well as industrial and academic partners throughout the State of Minnesota and nationwide.

The ITDD houses over 40 faculty, staff, postdoctoral researchers, and graduate students. Their cutting-edge scientific facilities and equipment span 20,000 square feet with laboratories organized into cores that focus on Chemical Process Development, High Throughput Screening, Lead and Probe Discovery, Medicinal Chemistry, and Pharmacology. We also offer purification and analytical services.

How To Apply

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).

Diversity

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.

Background Check Information

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

About the U of M

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

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